Author’s response to reviews Title: MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP) - Implementation of a national guideline in Canada Authors:

نویسندگان

  • Anne Synnes
  • Peter von Dadelszen
چکیده

Required revisions:  The abstract includes a clear statement supporting the need for MgSO4 for women at risk of very preterm birth to reduce the likelihood of cerebral palsy in the child, a brief description of the study design, methods, KT strategies used, the primary outcome, key results and conclusions of this project.  Recommendations: (a). Include a statement describing the extent of the practice gap (e.g. baseline practice rates compared to optimal), Thank you. We have included baseline practice rates in the introduction, as well an estimate in the abstract. (line 83) (b). Explicitly identify this as an implementation study current wording used is 'managed KT intervention' which is not clear and needs to be defined in the body of the paper if used, and The title has been changed to emphasize that this is an implementation project. As per Reviewer #1, we have changed „managed KT‟ to „multifaceted KT‟ for clarity. (c) Describe secondary outcomes of interest as well. We have clarified that our secondary outcomes of interest were related to safety: maternal effects and effect on neonatal resuscitation. Background and supporting literature Required revisions:  The authors provided rationale and supporting literature for use of MgSO4 for women at risk of very preterm birth to reduce the likelihood of cerebral palsy in the child.  They described issues that were perceived to be barriers to uptake of this practice (e.g. concerns about potential effect of MgSO4 on FHR and increased neonatal resuscitation, lack of understanding of neuroprotective mechanism of action and inadequate studies describing long-term adverse pediatric outcomes other than CP).  The purpose of the study is clearly stated: "increase 'optimal' use of MgSO4 (i.e., MgSO4 use when and only when indicated) to 80% of eligible women over four years (2011-15), as well as document any maternal or fetal adverse effects".

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منابع مشابه

MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP)—implementation of a national guideline in Canada

BACKGROUND Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32-34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP) was a multifaceted knowledge translation (KT) strategy for this practice. METHODS The KT strategy included national clinical practice guidelines, a n...

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Magnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada

BACKGROUND Administration of magnesium sulphate (MgSO4) to women with imminent preterm birth at <34 weeks is an evidence-based antenatal neuroprotective strategy to prevent cerebral palsy. Although a Society of Obstetricians and Gynaecologists of Canada (SOGC) national guideline with practice recommendations based on relevant clinical evidence exists, ongoing controversies about aspects of this...

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SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection.

OBJECTIVE To provide guidelines for the use of antenatal magnesium sulphate (MgSO4) for fetal neuroprotection of the preterm infant. OPTIONS Antenatal MgSO4 administration should be considered for fetal neuroprotection when women present at ≤ 31+6 weeks with imminent preterm birth, defined as a high likelihood of birth because of active labour with cervical dilatation ≥ 4 cm, with or without ...

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Update on the use of magnesium sulphate for fetal neuroprotection in preterm birth.

The administration of magnesium sulphate to mothers at risk for preterm birth for fetal neuroprotection has demonstrated to reduce the risk of cerebral palsy and gross motor dysfunction by 30-40%. Although there is controversy regarding the regimen of administration of magnesium sulphate, the gestational age limit, the extent of its potential benefit or even if it provides any benefit, current ...

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Magnesium sulphate for women at term for neuroprotection of the fetus.

BACKGROUND Magnesium sulphate is extensively used in obstetrics for the treatment and prevention of eclampsia. A recent meta-analysis has shown that magnesium sulphate is an effective fetal neuroprotective agent when given antenatally to women at risk of very preterm birth. Term infants account for more than half of all cases of cerebral palsy, and the incidence has remained fairly constant. It...

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تاریخ انتشار 2017